Siomek A (2012) NF-B signaling pathway and free radical impact
The goal is to take the smallest amount of medication to give you the desired effect
Initially used to treat type 2 diabetes and, more recently, approved for weight management, medications in this class include liraglutide (Saxenda), semaglutide (Ozempic/Wegovy), and dulaglutide (Trulicity)
Until then, clinicians should continue evidence-based practice and keep an eye on the evolving science
For instance, semaglutide received FDA and EMA approval for cardiovascular risk reduction in patients with obesity in 2024, and Novo Nordisk are also targeting the use of semaglutide in patients with obesity-related heart failure and metabolic associated steatohepatitis (MASH, formerly known as fatty liver disease)