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State-level or national coverage percentages are not a substitute for plan documents unless the methodology, population, benefit year, and source files are published and reproducible

Several mechanisms might explain possible benefits: Improved glycaemic control : Better blood glucose regulation may reduce endothelial dysfunction and microvascular damage, both implicated in ED pathophysiology Weight reduction : Significant weight loss can improve testosterone levels, reduce inflammation, and enhance vascular function Cardiovascular effects : GLP-1 agents may improve endothelial function and reduce cardiovascular risk factors that contribute to ED Reduced inflammation : These medications have been associated with anti-inflammatory effects that might benefit vascular health, though more research is needed Some observational studies have reported improvements in erectile function scores among men with diabetes treated with GLP-1 receptor agonists, though the evidence is limited and more robust research is needed

mTORC1 activity is inhibited in conditions of energy depletion coordinated with AMPK activity

Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production

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