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Today's GLP-1 medications already deliver significant results: semaglutide has shown average weight loss of about 15% of body weight, and tirzepatide up to 21%, in major clinical trials
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But even low doses appear to have a positive impact on opioid craving reduction, which is promising for managing potential side effects like nausea or excess weight loss
Unlike classical inflammation (characterized by heat, redness, and pain), neuroinflammation primarily involves the release of pro-inflammatory mediators (e.g., cytokines, chemokines, and ROS) by resident immune cells, particularly microglia, the CNSs innate immune effectors [110, 111]
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