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121 ChREBP inhibition markedly decreased the expression of L-PK, ACC, and FAS, but restored liver insulin sensitivity by restoring protein kinase B (Akt), and Foxo1 phosphorylation activity with insulin
It reduces the oxidative stress and production of melanin
Esto establece un crculo vicioso bioenergtico : menos GSH ms dao oxidativo menor capacidad de producir energa ms fatiga y disfuncin celular
Hyperpigmentation Hormonal changes may trigger an increase in melanin production, leading to skin darkening in certain areas
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