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[4] Whilst this increase is generally clinically insignificant, some patients may become more aware of their heartbeat, particularly if they are monitoring their health closely during weight loss treatment

In the ATTAIN-1 Phase 3 trial, the most frequently reported adverse events with orforglipron 36 mg versus placebo were nausea (33.7% vs 10.4%), constipation (25.4% vs 9.3%), diarrhea (23.1% vs 9.6%), and vomiting (24.0% vs 4.0%)

Any change you observe could come from either component, or their interaction

Be Ready for Your Prescriber to Tweak Your Bipolar Medication Beyond any special concerns with GLP-1s, any time you change your diet or lose weight, your medications may need to be adjusted, says Catanzano

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