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Exendin-4, a Glucagon-Like Protein-1 (GLP-1) Receptor Agonist, Reverses Hepatic Steatosis in Ob/Ob Mice
Medication works best when paired with sustainable nutrition and movement habits
During 72 weeks of treatment, people taking tirzepatide at doses of 5, 10, or 15 mg lost an average of 15.0%, 19.5%, and 20.9%, respectively, compared with just 3.1% in people taking a placebo
This O 2 surge oxidizes the PDX-1 transcription factor, suppressing insulin gene expression [342], while simultaneously activating the IRE1-JNK pathway to trigger -cell apoptosis [343]
Along the way, its key to pair the medication with lifestyle changes, like eating nutrient-dense food and being physically active most days
