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their moderate lipophilicity and low efflux liability support good brain exposure and moderate clearance, making them among the most CNS-compatible PDE1 scaffolds (Humphrey, 2014)
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Weeks 1-4 (1mg): the adjustment period Weight loss at 1mg is minimal
Due to the heterogeneity presented in the included studies (I 2 = 66%, P = 0.05), we used the random effects model (Fig
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