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Some medical conditions are associated with lower glutathione activity or higher oxidative stress
In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers
Also, remember to use sunscreen daily before going out
However, the efficacy of topical glutathione can vary, as it may not penetrate deeply enough to deliver significant antioxidant benefits