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The risk of NAION needs to be taken into account and may help to decide about a more conservative approach in the definition of beginning semaglutide for those subjects without a clear indication for that. When looking at the results of these studies, Bert said its important to note that when looking at the increases of percentages, it demonstrates that it is still very, very rare for a condition like NAION to occur

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These data demonstrate that high OxPhos signalling is associated with 5FU resistance and suggest that enhanced mitochondrial metabolism promotes treatment failure clinically

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