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Physicians prescribe these drugs with a structured titration phase that starts at a low dose and gradually increases over time

It may cause dehydration, nutrient loss, and fatigue, especially if it continues over time

There are some circumstances where deviating from NICE guidelines may be acceptable

UPDATE: Not surprisingly, on June 20, 2023, Novo Nordisk announced that it had filed lawsuits for trademark infringement and other claims relating to false advertising by the defendants in those cases

Patients taking other B-vitamin supplements or multivitamin preparations should inform their prescribing provider, as evaluation for potential additive effects or imbalances may be appropriate