However, despite encouraging findings, clinical translation remains limited due to the lack of sufficient human studies, variability in individual responses, and an incomplete understanding of their mechanisms in sepsis
The generation of the TMA was retrospective and patient information was de-identified, so a written informed consent was not required as deemed by COMIRB, as per the ethical standard defined by the Declaration of Helsinki
The lack of functional GSTU13 resulted in enhanced disease susceptibility toward several fungal pathogens including Erysiphe pisi, Colletotrichum gloeosporioides , and Plectosphaerella cucumerina (Pislewska-Bednarek et al., 2018)
Epidemiological studies indicate that the incidence of PND is approximately 23.8%, with rates as high as 50% in elderly cohorts (Silva et al., 2021