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Increasing fatty acid and ketone metabolism after a ketogenic diet also attenuated reductions in ATP, NAD, mitochondrial fragmentation, and myelination in a murine diffuse axonal injury model, while treatment with ketone bodies reduced neuronal/myelin damage induced by glucose deprivation in vitro [96]
3739 While it is encouraging that the weight loss achieved with GLP-1/GIPGLP-1 receptor agonists approaches levels typically seen after bariatric procedures such as gastric bypass or sleeve gastrectomy, the rapid regain of a significant portion of the lost weight after treatment discontinuation, accompanied by a reduction in lean body mass, raises new clinical concerns
Some patients achieve excellent results with semaglutide alone, especially if their GLP1R genetic variants favor strong single-pathway sensitivity
Some people may notice improvements within a few weeks, while others may require several months of consistent use
Many mothers and physicians choose to delay GLP-1 initiation until weaning to eliminate theoretical lactation exposure
