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Activating this pathway helps neurons survive, strengthens synaptic connections, and makes neurons more resistant to injury
In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (2015)
The STEP 1 trial is a useful reference point
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An outlier in the eukaryotic lipase family is found in fungi, specifically Candida rugosa lipase 31 , which uses a tunnel for substrate binding rather than a hydrophobic pocket
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