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It can also cause skin lightening by converting melanin to a lighter color and deactivating the enzyme tyrosinase, which helps produce the pigment
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International journal of cosmetic science , 27 (5), 271278
The National Cancer Institute warns that "too many enemas of any kind can cause changes in normal blood chemistry, chemicals that occur naturally in the body and keep the muscles, heart, and other organs working properly." Some experts specifically warn against using coffee as the stimulant in an enema, citing a lack of research on its potential effects
Vitamin B12 deficiency recovery can take time, six to twelve months, but with ongoing supplements, improvement should be gradual
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