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Oral semaglutide 25 mg (Wegovy pill) , FDA-approved December 22, 2025, is the first oral GLP-1 approved for chronic weight management
Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]
In June 2024, the National Health Commission (NHC) and 16 government ministries jointly released the Implementation Plan for the Year of Weight Management Initiative ( , calling for a scientific understanding of weight management and appropriate medical intervention
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