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In leptin-deficient ob/ob mice, sitagliptin at 50 mg/kg daily for 4 weeks ameliorated weight gain, metabolic disorders, and steatosis in the liver as well as insulin sensitivity
doi: 10.1038/s41392-023-01496-3, 6
But, like all medications, FDA-approved GLP-1s have risks and benefits
Dulaglutide (Trulicity) has the most significant entry into brain cells, at 61.8%, among the available GLP-1 agonists
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