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Gastrointestinal changes are common

The effect of rosiglitazone on cellular growth was associated with cell cycle arrest and with an increase of cyclin-dependent kinase inhibitors p21 (cip1) and cyclin-dependent kinase regulator p27 (kip1), a decrease of cyclin D1, and inactivation of Rb protein

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During macroscale tensile loading, tendons strain stiffen, as is evidenced by the distinct nonlinearity, or toe region, in the load-displacement curve that becomes linear with increased displacement prior to ultimate failure (Fig