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Additionally, when outpaced by excessive debris accumulation from intraplaque cell death, efferocytes die, leading to the release of inflammatory DAMPS and unhindered necrotic core formation 2

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A one-week titration at 1 mg may improve tolerability before advancing to the full 2 mg dose

We estimated physiological NADP + and NADPH levels in our healthy cohorts, based on frozen sample results, and validated the theoretical calculation by analyzing fresh whole blood samples from 12 additional healthy volunteers (Supplementary Table 5)