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Drugs like retatrutide, CagriSema, survodutide, and orforglipron are designed to build on what Ozempic started
Phosphorylation at S3 inhibits NLRP3 activation, whereas phosphorylation at S194, mediated by JUN N-terminal kinase 1 (JNK1), promotes it
In clinical trials, retatrutide is administered as a subcutaneous injection, meaning an injection under the skin
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For example, other antidiabetic agents (such as insulin, metformin, glyburide, sitagliptin, and canagliflozin) taken along with GLP-1 RAs potentiate hypoglycemic risk and may necessitate dose adjustments
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