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Meanwhile, another study in 16% weightloss over 64 weeks at microdose levels The New England Journal of Medicine shows just 33% of the dose of one popular GLP-1 drove 72% of the weight loss at week 72 with a lower side effect profile

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Taking into account that SGLT-2i and GLP-1RA are recommended as therapeutic alternatives by many clinical guidelines, usually as second-line treatments after first-line metformin, new users of SGLT-2i appear to be a suitable active comparator group

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