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Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
Pharmacology 101: Activation of the GLP-1 receptor by GLP-1 RAs inhibits the release of the hormone motilin, which is important in stimulating gastric motility
Those who claim these things dont work are simply addressing problems that dont even exist
Conclusion Navigating your health journey while on semaglutide requires vigilance and open communication with your healthcare team
Side effect preparation: Nausea is the most reported side effect, particularly during the first four to eight weeks as doses increase
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