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Poly(GR) in C9ORF72-related ALS/FTD compromises mitochondrial function and increases oxidative stress and DNA damage in iPSC-derived motor neurons
However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination
Discussion: This report highlights the positive impact of continuous subcutaneous insulin infusion in patients with T1D and genetic comorbidities such as Silver-Russell syndrome
Pharmacokinetics of metformin after intravenous and oral administration to man
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