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The practical motivation for the route is threefold: avoidance of first-pass hepatic metabolism, rapid absorption via the highly vascular respiratory epithelium, and partial access to the CNS via the olfactory and trigeminal pathways that bypass the blood-brain barrier
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They are thus difficult or impossible to apply to describe the hygroscopic behavior of sub-10 nm nanoparticles, which can often be supersaturated in concentration compared to bulk solutions (Cheng et al., 2015)
Journal of Drug Delivery Science and Technology
BPC-157 and TB-4 Frag, however, are available in both injectable and oral forms, and they are very effective in both forms
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