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The research ethics committee of the School of Medicine, Tohoku University, approved this study, which was conducted in accordance with the ethical guidelines of the 1975 Declaration of Helsinki
This eliminates the need for intrusive, irritable needles, which generate medical waste, pose a danger of infection, and need to be administered by a medical expert [215]
Consequently, the very mechanisms that enable a probiotics beneficial effects may also heighten its capacity to cause disease (560)
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