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Long-term Results: According to 2026 data, patients on tirzepatide or semaglutide often reach their peak weight loss between month 10 and month 14 . Total Loss: Most successful patients see a total reduction of 15% to 22% of their starting weight by the one-year mark. The Shift: At this stage, you and your doctor will discuss whether to stay on a "maintenance" dose or begin a very slow taper, depending on your metabolic health goals
in people who already had heart disease
However, one theory suggests that Ozempic, like other medications, can alter the balance of chemicals in the brain, which could potentially lead to mood changes or depression
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Second, weight loss had not plateaued at 80 weeks: in a pre-specified extension involving 532 participants with a baseline BMI of 35 or above, those continuing to 104 weeks reached an average of 30.3 per cent
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