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However, their therapeutic efficacy is significantly influenced by pharmacokinetic factors, including absorption, distribution, metabolism and excretion, which directly impact their bioavailability [99]
They demonstrated the feasibility of using in vitro-synthesized mRNA as an information carrier to guide somatic protein synthesis
A parallel line of work by Chang and colleagues (J Appl Physiol, 2011) examined cultured rat Achilles tendon fibroblasts and reported increased outgrowth, survival and migration alongside elevated phosphorylation of focal adhesion kinase (FAK) and paxillin, the adaptor pair coupling integrin engagement to cytoskeletal reorganisation
Crystal structure-based comparison of two NAMPT inhibitors
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