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As shown in Figure 5M, mechanistic studies demonstrated that the electrical stimulation generated by the piezoelectric membrane exerts therapeutic effects by activating the PI3K/AKT signaling pathway: the electric field promotes PI3K-catalyzed generation of PIP 3 , which subsequently activates AKT serine/threonine kinase, triggering a cascade of intracellular events that regulate critical biological processes, including cell survival, proliferation, and migration

A 2013 study (PMID 23106397) employed DES(1-3) IGF-1 as an IGF1R-activating tool in oral squamous cell carcinoma cells to investigate resistance mechanisms to EGFR tyrosine kinase inhibitors

Drug metabolism has a significant effect on pharmacokinetic, pharmacodynamic and safety of a drug [22]

10.1161/01.RES.0000183733.53101.11

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