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The medication activates GLP-1 receptors to suppress appetite, slow stomach emptying, and improve blood sugar levels
Nausea and reduced appetite are among the most frequently reported side effects of GLP-1 medications, particularly during the initial weeks of treatment or following dose increases
R.LiptonM
METABOLIC EFFECTS AND INSULIN SENSITIVITY Glucose Metabolism Insulin sensitivity: improvement in the HOMA-IR index 30-40% Glucose uptake: increased muscle/liver uptake 25% Gluconeogenesis: Modulation of Hepatic Glucose Production HbA1c: reduction of 0.40.61 TP3T in diabetic models Plasma Lipid Profile Triglycerides: reduction of 2535% Total cholesterol: decrease of 10151 TP3T HDL: increase of 8121 TP3T LDL: Reduction of small, dense particles 20% ApoB: decrease of 15% Liver Function Hepatic steatosis: reduction in liver fat 40-50% (NMR spectroscopy) ALT/AST: Improves 25-30% markers in NAFLD Hepatic Insulin Sensitivity: Signaling Restoration De novo lipogenesis: inhibition of hepatic lipid synthesis 3
NEJM 2025
