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Data availability Nucleotide sequences of codon-optimized genes can be found in Supplementary Table 6

2g Vitamin C: Vitamin C amplifies collagen production, enhances skin elasticity, and strengthens your immune system

Yadav et al., 2015

At standard dosing of 1-2mg daily, a 100mg vial provides roughly 50-100 days of supply

Beyond glycemic effects, ischemiareperfusion injury is strongly linked to mitochondrial ROS generation at reperfusion (including succinate-associated mechanisms), providing a rationale for exploring perioperative mitochondria-targeted metabolic modulation in IR-prone procedures such as cardiopulmonary bypass (119, 120)