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Endoplasmic reticulum stress related factor IRE1 regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy
By supporting improved insulin sensitivity and metabolic regulation, GLP-1guided therapy may contribute to improvements in markers associated with cardiovascular health
The STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) documented weight loss ranging from 5-20% of baseline body weight depending on dose and individual factors
As mitochondria fail to maintain cellular energy, neuronal survival is compromised, and apoptotic pathways are activated (Davidson et al., 2001) (Figure 1)
