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The NDC number for the specific B12 product must also be reported on Medicare claims

Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

Some people, however, feel that they would benefit from additional doses in-between, based on their individual symptoms and response to the injections