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Semaglutide, a GLP-1RA, mitigates seizure severity and cognitive impairment through the inhibition of the lipopolysaccharide (LPS)- and nigericin-induced NLRP3 inflammasome pathway, reducing lactate dehydrogenase (LDH) release by microglial cells [53]
Verdict at a Glance Semaglutide is the established standard with three FDA approvals, massive clinical evidence, and proven cardiovascular outcomes
Semaglutide: Selective GLP-1 receptor agonist that suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion
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