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You should always follow the instructions given by your prescribing clinician, clinic, or pharmacy

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Instead of targeting a single receptor, retatrutide activates three hormone receptors involved in appetite and metabolism: GLP-1 receptor GIP receptor Glucagon receptor Because it activates all three pathways, it is often called a triple agonist

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Certain factors may increase the likelihood of experiencing bloating on GLP-1 therapy, including: Pre-existing gastrointestinal conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or small intestinal bacterial overgrowth (SIBO) Rapid dose escalation without adequate titration periods Dietary factors , particularly high intake of fermentable carbohydrates (FODMAPs), fatty foods, or carbonated beverages Concurrent medications that affect gastrointestinal motility Patients should be aware that GLP-1 receptor agonists have been associated with more serious gastrointestinal adverse effects, including pancreatitis (inflammation of the pancreas) and gallbladder disease

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