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Furthermore, gene expression analysis of intestinal epithelial cells (IECs) showed no significant differences in mRNA levels of Gip and Glp1 and the potential upstream transcription factor regulatory factor X6 ( Rfx6 ) in duodenum, jejunum, ileum, and colon, while expression of pancreatic and duodenal homeobox 1 ( Pdx1 ) was higher in jejunum of PAR2-R38E mice when compared with PAR2-G37I and WT mice (Supplemental Figure 2C)
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