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Though these early studies are promising, clinicians still recommend stopping treatment during pregnancy
Sharing a 94% structural homology with native human GLP-1, Semaglutide is distinguished by three modifications: 1) amino-acid substitutions at position 8 (alanine to -aminoisobutyric acid or Aib) and position 34 (lysine to arginine), and acylation of the lysine in position 26 with a spacer consisting of two 8-amino-3,6-dioxaoctanoic acid (ADO) moieties, a glutamic acid moiety, and a C-18 fatty di-acid side chain (Lau et al., 2015)
However, overlap exists in downstream effects on glucose and lipid metabolism, meaning additive effects are possible but not guaranteed for every person
Keamanan penggunaan jangka panjang atau dosis tinggi belum terbukti, sehingga penggunaannya perlu lebih berhati-hati
Fiber supplements (psyllium husk, methylcellulose) can help, but introduce them slowly and drink extra water
