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Estimation of premorbid IQ in individuals with Alzheimers disease using Japanese ideographic script (Kanji) compound words, Japanese version of National Adult Reading Test

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

Zhang DD, Lo S-C, Cross JV, Templeton DJ, Hannink M

This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

TB-500 also appears to be generally well-tolerated, but again, safety data derived from adequately powered clinical trials is lacking