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Have obesity as the main underlying cause of prediabetes

Both pharmacological inhibition and partial deletion of endothelial PFKFB3 reduced tumor vascularization and metastasis, while also increasing vessel stability, which aided drug delivery and enhanced the effect of chemotherapy in a murine liver cancer model (132)

A recent study demonstrated the protective role of GLP-1R receptors against hyperglycemia- induced endothelial to-mesenchymal transformation which is a crucial component of diabetic endothelial injury in cardiomyopathy, nephropathy, and retinopathy

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Deletion of GIP receptor has been found to counteract high-fat diet induced weight gain in mice, suggesting a causal role of GIP in development of obesity [36]