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Hence, contrary to the expectation that hematopoietic progenitors would be geno-protected throughout life, we found that progenitor cells from aged killifish carry higher levels of DNA damage compared to all other cell types in the hematopoietic organ, as recently shown in aged mammalian HSCs 77,78 , and to some extent, in aged-adult humans 79

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Nonetheless, more research needs to be done to elucidate NP interactions with the diverse regions of the brain and the ways in which these cell-cell interactions change under disease conditions, especially with the increasingly detailed maps of brain cell functions and interactions that are now available

In ApoE 4 carriers, increased AST/ALT ratios and reduced ALT levels were significantly associated with higher brain A load and accelerated cognitive decline [63]