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Figure: chemical structure of Tirzepatide
In a phase 1 trial by Martin and colleagues, observations at week 6 comparing tirzepatide vs once-daily liraglutide and placebo have shown that the use of the latter, provides a reduction on the desire for high-fat and high-sugar food by lowering activation in the cingulate gyri, hippocampus and orbitofrontal cortex assessed by MRI and blood-oxygen-level at these areas, meaning less appetite, early satiety, and less food craving with more reduction on weight loss at short term (181)
Youll probably also notice that your desire for high-sugar or high-fat foods isn't as strong
After approximately five half-lives, a medication is considered largely eliminated from the body
This disparity could exacerbate negative emotions, thereby further increasing the risk of depression [44]
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