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Phase 2 Body Composition Findings Average total weight loss at 12 mg: 24.2% Fat mass reduction: Significantly greater than placebo and comparator drugs Lean mass preservation: Comparable or superior to existing treatments Visceral fat reduction: Particularly pronounced (correlating with metabolic improvements) What makes these findings particularly relevant for bulking applications is the context of how participants were eating

For instance, administration must occur in a fasted state (at least 2-3 hours post-meal) because elevated insulin and blood glucose can significantly blunt the pituitarys response to secretagogues

10.1210/me.2014-1062 118 PavelcovaK.BohataJ.PavlikovaM.BubenikovaE.PavelkaK.StiburkovaB