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And your genes may hold the key here.[ref][ref] Theres currently a push in psychiatry to include in the DSM a specific subtype of depression linked to inflammation.[ref] Inflammation-driven depression is characterized by:[ref] sleep problems tiredness, lack of energy changes in appetite anhedonia (meh, feeling like nothing matters) Genetic studies show causality: One way to determine if inflammation is a root cause of mood disorders is to look at the genetic variants that increase susceptibility to depression or anxiety

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Mallory Fox, a personal trainer based in Scottsdale, Arizona, said she's had many prospective clients ask about whether she works with people taking GLP-1s, to the point where she's considered developing an online program for those on the medications