During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period
Conditions such as intestinal or stomach problems, poor nutrition, HIV, pregnancy, old age, veganism and alcoholism can contribute to vitamin B12 deficiency
Moderate deficiency may include obvious macrocytic anemia, glossitis, as well as some mild or subtle neurological features, such as distal sensory impairment.[] Severe deficiency is characterized by bone marrow suppression, neurological features, and the risk of cardiomyopathy
Kotzakioulafi, A
Whats happening: Sustained dual-action fat metabolism is reshaping body composition