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Hydrolysis is the breaking of peptide bonds through reaction with water molecules, a process that accelerates significantly with rising temperature this is the primary reason reconstituted peptides must be refrigerated rather than left at room temperature

PMID: 184 Neves da SilvaHVMellerRLOgundipeEARochonPJ

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Holding your breath and straining when trying to pass a stool causes greater pressure in the veins in the lower rectum