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Reactions of the Oxidative Phase: Conversion of glucose-6-phosphate to 6-phosphogluconolactone by glucose-6-phosphate dehydrogenase : irreversible, rate limiting step of the pathway inhibited by NADPH which competes for NADP + binding NADPH produced, C=O double bond formed Km for NAD + is 1000-fold higher than for NADP +
NAD+ is used to support the oxidation side of the deficit Weeks 58 Steady progress Fat loss stabilizes at 12 lb/week Appetite Becomes mechanical rather than emotional Energy Often steadier when NAD+ support, protein, hydration, and sleep are all in place Challenge May need reminders to eat enough protein Weeks 912 Consolidation Scale progress may slow
Christ A, Lauterbach M, Latz E
protect from light and avoid freezethaw cycles
However, injections require once-weekly administration and involve needle anxiety for certain patients, whereas oral semaglutide is taken daily but requires no injection skills or sharps disposal
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