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These copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro (Sugimoto et al., 1995), reducing local DHT production

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[1] Unlike fat-soluble vitamins that accumulate in body tissues, water-soluble vitamins are generally excreted through urine when consumed in excess

Its been reported that as many as 40% of patients in the US may have suboptimal energy levels