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It is also crucial to recognize that an increasing number of both preclinical and clinical research studies indicate that some therapeutic benefits of GLP-1 RAs, especially their anti-inflammatory and cytoprotective effects, may not be entirely connected to their primary use related to body weight
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The increase in lactate that we detected points towards a defect in oxidative energy metabolism, but this conclusion must be treated cautiously given the difficulty of measuring lactate in the presence of the much larger and broader macromolecule (MM) resonance at ~1.35 ppm, with the lactate signal being a small shoulder on that peak (Fig
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Pharmacological inhibition of glycolysis with 2-deoxyglucose reduced inflammatory signaling, posttraumatic hyperexcitability and epileptiform activity [66, 67]
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