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Our animal models, induced using endothelin-1 (ET-1), reflect clinically relevant cerebral I/R conditions yet may not fully capture the complexity of human pathophysiology, including inter-individual anatomical variation and comorbidities ( in vivo , including their potential off-target effects and clearance pathways
Human mutation, 13(5), 362375.[PubMed] [Wiley] Lalouschek, W., Aull, S., Serles, W., Schnider, P., Mannhalter, C., Lang, T., Deecke, L., & Zeiler, K
More recent research (Tian et al., 2023) shows curcumin may also act as a natural TGR5 agonist, enhancing GLP-1 release through the gut microbiota-bile acids axis
found that GHK-Cu cream improved skin laxity, clarity, and appearance, reduced fine lines and the depth of wrinkles and increased skin density and thickness when applied to facial skin for 12 weeks [14]
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