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Secondly, several studies have demonstrated that vitamin B2 can promote the self-renewal and osteogenic differentiation capacities of mesenchymal stem cells via regulating multiple signal pathways, such as p38 MAPK/BMP-2/Smad1/5/9 signaling pathway [12], AKT/FAK/CaMKII pathway [13], and caspases-3/8/9 pathway [13]