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(Staud points out that a more acidic mileu in the muscles possibly produced by low oxygen conditions in FM primes the pain receptors in the muscles to act up.) EEG studies suggest the muscles in FM have trouble relaxing, causing them to stay in a more contracted state a state that can be associated with hypoxia and causes increased pain sensitivity
Through phosphorylation inhibition of 4E-BP1, mTORC1 can increase ODC translation and promote polyamine synthesis (Rousseau et al., 1996)
35 (12), e22035
Cai FF, Bian YQ, Wu R, Sun Y, Chen XL, Yang MD, Zhang QR, Hu Y, Sun MY, Su SB (2019) Yinchenhao decoction suppresses rat liver fibrosis involved in an apoptosis regulation mechanism based on network pharmacology and transcriptomic analysis
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