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In addition, 4 weeks of training at 70% of maximal oxygen uptake significantly promoted the exercise-induced increase in serum SPARC level

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(2017) ( 40 ), who described the role of copper and copper-binding antioxidant compounds against NAFLD in the development and progression of NAFLD, patients with NAFLD had lower serum levels of copper and this deficiency promotes changes in lipid metabolism, insulin resistance and negative regulation of mitochondrial beta-oxidation, alterations related to increased oxidative stress and the pathophysiology of the disease under study